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Bioaktivitas Ekstrak Daun Tapakdara (Catharanthus roseus) terhadap Kadar Kreatinin dan Kadar Ureum Darah Tikus Putih (Rattus norvegicus)

Dr. Drh. I Ketut Anom Dada, MS., I KETUT ANOM DADA (2014) Bioaktivitas Ekstrak Daun Tapakdara (Catharanthus roseus) terhadap Kadar Kreatinin dan Kadar Ureum Darah Tikus Putih (Rattus norvegicus). Buletin Veteriner, 6. ISSN 2085-2495

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Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui bioaktivitas ekstrak daun Tapakdara (Catharanthus roseus) terhadap kadar kreatinin dan kadar ureum darah pada tikus putih (Rattus norvegicus) yang diberikan secara oral. Sebanyak 24 ekor tikus putih jantan (250-260 gram/ekor) dibagi menjadi tiga perlakuan, masing-masing perlakuan terdiri dari 8 ekor. Perlakuan 1 sebagai kontrol yang hanya diberikan aquades, perlakuan 2 diberikan ekstrak dengan dosis 100 mg/kg berat badan dan aquades, perlakuan 3 diberikan ekstrak dengan dosis 200 mg/kg berat badan. Pemberian ekstrak dilakukan selama 8 hari setelah satu minggu masa adaptasi. Pemeriksaan kadar kreatinin dan urea darah dilakukan pada hari ke-13. Hasil penelitian menunjukkan bahwa tikus yang diberikan ekstrak daun Tapakdara dengan dosis 100-200 mg/kg berat badan kadar kratininnya lebih tinggi sangat nyata (P<0.01) dibandingkan dengan kontrol, walaupun masih dalam batas nilai normal. Sedangkan tikus yang diberikan ekstrak daun Tapakdara dengan dosis 100-200 mg/kg BB juga kadar ureum darah nyata (P<0.05) lebih tinggi dibandingkan dengan kontrol, yang juga nilainya masih dalam kisaran nilai normal. Kata kunci : Catharanthus roseus, kreatinin, urea darah, Rattus norvegicus ABSTRACT The aim of the study was to evaluate the bioactivity of the Tapakdara leaf extract (Catharanthus roseus) on the creatinine and blood urea levels in rat (Rattus norvegicus). Tweenty four male rats (250-260 gram body weight) were devided into three goups, with 8 animals in each group. Group 1 as a control group that was geven placebo, the group 2 was treated with 100 mg/kg body weight of leaf extract orally and the group 3 was treated with 100 mg/kg body weight of leaf extract orally. The animals were treated during 8 days after one week adaptation period. The examination of ceratinin and Blood Urea Nitrogen (BUN) were done in the last day of treatment. The result of the study indicated that the creatinin level of rats treated with 100 and 200 mg/kg BW was high significantly higher (p<0.01) than control group, however the creatinin level was in range of normal value. The level of Blood Urea Nitrogen of rats were treated with leaf extract of Tapakdara 100-200 mg/kg BW was significantly hihger (p<0.05) than control group, it was also in normal value. Keywords: Catharanthus roseus, creatinin, Blood Urea Nitrogen (BUN), Rattus norvegicus

Item Type: Article
Uncontrolled Keywords: -
Subjects: L Education > L Education (General)
Divisions: Faculty of Law, Arts and Social Sciences > School of Education
Depositing User: Mr. Repository Admin
Date Deposited: 07 Jun 2016 21:58
Last Modified: 21 Jun 2016 05:58
URI: http://erepo.unud.ac.id/id/eprint/1508

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