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Intravenous Administration of Chicken Immunoglobulin Has a Curative Effect in Experimental Infection of Canine Parvovirus

Dr. Drh. I Gusti Ayu Agung Suartini, M.Si. , I GUSTI AYU AGUNG SUARTINI (2014) Intravenous Administration of Chicken Immunoglobulin Has a Curative Effect in Experimental Infection of Canine Parvovirus. Global Veterinaria, 13. ISSN ISSN 1992-6197

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Abstract

Abstract: Chicken immunoglobulin Y (IgY) may provide a new modality in the therapy of various infectious fatal animal and human diseases. This study presents evidence of its efficacy for canine parvovirus (CPV), which is a highly infectious, fatal viral disease in dogs. Hens were injected with formaldehyde-inactivated, tissue culture-derived, field isolates to produce IgY. Additional doses were administered 2 and 4 weeks following the first injection. IgY purified from the collected sera contained two proteins with molecular weights of 68 and 24 kDa. In feline kidney tissue culture, the 50% protective dose (PD50) was found to be 10 . The effectiveness 8 of intravenous (IV) IgY immunotherapy was tested in dogs after oral challenge with a highly pathogenic CPV isolate. The recovery rates for the dogs treated with 1,000 and 10,000 PD50 were 25% and 100%, respectively. The higher dose was more effective in generating a protective antibody titer and in suppressing infective virus excretion in stool. We conclude that yolk-derived chicken immunoglobulin can be administered intravenously in dogs and is effective for the treatment of a severe clinical course of experimental CPV-2 infection. Key words: IgY Intravenous Immunotheraphy Canine Parvovirus

Item Type: Article
Uncontrolled Keywords: -
Subjects: L Education > L Education (General)
Divisions: Faculty of Law, Arts and Social Sciences > School of Education
Depositing User: Mr. Repository Admin
Date Deposited: 07 Jun 2016 21:58
Last Modified: 21 Jun 2016 05:58
URI: http://erepo.unud.ac.id/id/eprint/1808

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