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The Influence of Euphorbia Milli Flower Extract in the Activity of th 17 trough IL-17 secretion in mycobacterium tuberculosis Infected Mice

Dr. dr. I DEWA MADE SUKRAMA, MSi, Sp.MK(K), I DEWA MADE SUKRAMA (2016) The Influence of Euphorbia Milli Flower Extract in the Activity of th 17 trough IL-17 secretion in mycobacterium tuberculosis Infected Mice. International Journal of Science and Research (IJSR), volume. ISSN 2319-7064

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Abstract

The present study was conducted to study Euphorbiamilii flowerextract (EM) in increasingthe activity ofTh17 cellsthroughIL-17 secretion. Thiswas an experimental study with Post TestOnly ControlGroupdesign. 24 BalbC, male,were divided in to 6 groups of treatment whichwere observedat firstandthird week. GroupK1and K2arenegativecontrols; P1andP3weregivenOAT and M.tbinfected; while theP2andP4were infected M.tb, givenOATandEM. Terminations of K1, P1andP2were inthe firstweek, while K2, P3andP4 were terminated inthe thirdweek. Pulmonaryorgans were removed for examinationofIL-17 by ELISA. The result showed mean of level ofIL-17 inK1, P1, P2, K2, P3andP4respectivelyis81.18; 90.00; 88.65; 87.53; 75.45and87.53 pg/ml. EMextractsincreased the concentration ofIL-17 in the third weekhigher than thegroup thatdid not receivethe extractbut the difference wasnot significantly. It happenedprobablybecausea lot offactors thataffect the stability ofIL-17, thus affecting theoutcome. It is necessary forfurther research onthe mRNAexpression ofIL-17, so thatthe influence factorscan be minimized.

Item Type: Article
Uncontrolled Keywords: Euphorbia milii, Mycobacterium tuberculosis, Th17, IL-17
Subjects: L Education > L Education (General)
Divisions: Faculty of Law, Arts and Social Sciences > School of Education
Depositing User: Mr. Repository Admin
Date Deposited: 07 Jun 2016 21:58
Last Modified: 21 Jun 2016 05:58
URI: http://erepo.unud.ac.id/id/eprint/7806

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