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ACUTE PROMYELOCYTIC LEUKEMIA

Dr. dr. Anak Agung Wiradewi Lestari, S.Ked, Sp.PK, Anak Agung Wiradewi Lestari (2013) ACUTE PROMYELOCYTIC LEUKEMIA. Prosiding SURAMADE III, -. ISSN -

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Abstract

Acute Promyelocytic Leukemia (APL) is a subtype of Acute Myeloid Leukemia (AML) with distinctive biologic and clinical features. APL is relatively uncommon, the frequency being estimated as 10% of acute leukemias. The disease is very uncommon in children less than 10 years of age. Its incidence increases steadly during the teen years, reaches a plateau during early adulthood, and remains constant until it decreases after 60 years. Every sign and symptom that present on patient with APL are due to infiltration of bone marrow with leukemic cells and result in failure of normal hematopoiesis. Without the normal hematopoietic elements, the patient is at risk for life-threatening complications of anemia, having infection due to functional neutropenia, and hemorrhage due to thrombocytopenia, disseminated intravascular coagulation, fibrinolysis, and proteolysis into mature cells. We reported one case of a nine-year-old female with pale, limp, recurring fever, hematoma and petechia. Physical examination revealed pale in conjunctiva, gingival hypertrophy, and hepatomegaly. Complete blood count showed normochromic normocytic anemia, thrombocytopenia, and leukopenia, with neutropenia. Bone Marrow Aspiration revealed a bundle of auer rod, promyelocyte 60 %, myeloblast 2 %, concluded as AML(M3). The patient provided chemoterapy with vitamine A, daunorubicine, and cytarabine, but the condition was decreased and finally died after 1st period of chemotherapy

Item Type: Article
Uncontrolled Keywords: acute promyelocytic leukemia, children
Subjects: L Education > L Education (General)
Divisions: Faculty of Law, Arts and Social Sciences > School of Education
Depositing User: Mr. Repository Admin
Date Deposited: 07 Jun 2016 21:58
Last Modified: 21 Jun 2016 05:58
URI: http://erepo.unud.ac.id/id/eprint/7874

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