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NEOPTERIN AS BIOMARKER FOR CARDIOVASCULAR EVENTS IN ACUTE CORONARY SYNDROME PATIENTS

Dr. dr. Anak Agung Wiradewi Lestari, S.Ked, Sp.PK, Anak Agung Wiradewi Lestari (2013) NEOPTERIN AS BIOMARKER FOR CARDIOVASCULAR EVENTS IN ACUTE CORONARY SYNDROME PATIENTS. proceeding 13th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress, -. ISSN ISBN 978-602-14796-0-5

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Abstract

Background. Acute coronary syndrome (ACS) is a clinical manifestation of coronary atherosclerosis. In recent years, inflammation is known to have an important role in the pathogenesis of atherosclerosis and plaque instability. Several inflammatory markers have also been studied in relation to cardiovascular events (CVE) such as death due to vascular causes, AMI, stroke, and recurrent cardiac ischemia. This study aims to demonstrate that high levels of neopterin is biomarker of CVE risk in ACS patient. Material and method. acute coronary syndrome undergoing treatment at the Intensive Cardiac Care Unit (ICCU) Sanglah Hospital in Denpasar and willing to be subjects in research. Subjects were observed until the CVE occur or until a period of six months ( 180 days). Results. Sixty six patients with ACS treated at intensive cardiac care unit Sanglah Hospital Denpasar Bali. There were 13 patients (19.7%) with UA, 11 patients (16.7%) had NSTEMI, and 42 patients (63.6%) STEMI. In observations over a period of 6 months, found as many as 15 (22.7%) patients with CVE, which consisted of 11 (16.7%) patients vascular death, 3 (4.5%) patients had IMA and 1 (1.5%) patients experienced reccurent cardiac ischemia. Of the 15 subjects with CVE, 13 subjects with STEMI and 2 remaining with UA. Median value neopterin is 15.18 nmol/L. CVE incidence rate on the group of subjects with high level of neopterin is 5 times greater than the group with low levels of neopterin., p = 0.005. Discussion. When confounding factors such as dyslipidemia, diabetes, hypertension, obesity, smoking and age are controlled, only neopterin levels affect the incidence CVE with the incidence rate ratio of 6.46 (95% CI: 1.45 to 28.74), p = 0.014. Further study with a longer observation time is needed to obtain a more appropriate results.

Item Type: Article
Uncontrolled Keywords: neopterin, Acute coronary syndrome, cardiovascular events
Subjects: L Education > L Education (General)
Divisions: Faculty of Law, Arts and Social Sciences > School of Education
Depositing User: Mr. Repository Admin
Date Deposited: 07 Jun 2016 21:58
Last Modified: 21 Jun 2016 05:58
URI: http://erepo.unud.ac.id/id/eprint/7875

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