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In Vivo radioadaptive response of white blood cells (leukocytes) quantity in mouse (mus muscullus l) blood to Co-60 gamma radiation exposure

Gusti Ngurah Sutapa,S.Si, M.Si, GUSTI NGURAH SUTAPA, S.Si, M.Si (2014) In Vivo radioadaptive response of white blood cells (leukocytes) quantity in mouse (mus muscullus l) blood to Co-60 gamma radiation exposure. International Conference on the Sources, Effects and Risks of Ionizing Radiation (SERIR), 01. ISSN ISBN : 978-602-70092-0-2

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Abstract

Low radiation dose induction might changes the mechanism of cellular and molecular systems, with a certain condiation; it can protect cells to reduce the effect from subsequent high dose. This phenomenon is called radioadaptive response. In this work radioadaptive response has been investigated in 80 male mice with age of 37 to 46 days old, and the body weight of 23.79 to 26.66 grams. These mice were divided into 4 group, one group was as control, and the other groups were treated with Co-60 gamma radiation which called as treatment without adaptive, adaptive I, and adaptive II responses. To the mice from the group of treatment without adaptation, challenge doses of 1.0, 1.5, 2.0, 2.5, and 3.0 Gy were delivered. The same challenge doses were given to the adaptive I and adaptive II treatment group directly and 5 minutes after receiving the adaptive of 0.1 Gy. The number of total leukocytes counts of the control group wes (9.51±0.81)x103/?l. In general radiation doses decrease the leukocytes counts from 3 treated group and linearly related with the increasing dose. The effect radioadaptive response of the adaptive II treatment group was relatively higher, which were illustrated by the linear coefficient of the group without adaptive, adaptive I, and adaptive II with the value of -0.18, -0.15, and -0.11, respectively. These results indicated that the adaptive response increased when there was interval delivering time between adaptive and challenge dose.

Item Type: Article
Uncontrolled Keywords: Induction of radiation, adaptive response, the dose challenges
Subjects: L Education > L Education (General)
Divisions: Faculty of Law, Arts and Social Sciences > School of Education
Depositing User: Mr. Repository Admin
Date Deposited: 07 Jun 2016 21:58
Last Modified: 21 Jun 2016 05:58
URI: http://erepo.unud.ac.id/id/eprint/8147

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