Erythrocyturia and proteinuria conversion in post-streptococcal acute glomerulonephritis

dr. I Ketut Suarta, SpA(K), I Ketut Suarta (2006) Erythrocyturia and proteinuria conversion in post-streptococcal acute glomerulonephritis. Paediatrica Indonesiana, 46 (3-4). ISSN E-ISSN 2338-476X | P-ISSN 0030-9311

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Background Acute glomerulonephritis (AGN) is a sudden onset
of macroscopic hematuria and edema. The chronic post-streptococcal
acute glomerulonephritis (PSAGN) can be predicted if microscopic
hematuria, proteinuria, and low serum complement C3
level are present for a period exceeding six months after initial onset
of illness. It is prudent to follow the course of PSAGN until proteinuria
normalizes and microhematuria disappears in urinalysis.
Objective To acquire the time of erythrocyturia and proteinuria
conversion in post-streptococcal acute glomerulonephritis (PSAGN)
among children.
Methods A retrospective cohort study on children with PSAGN
was conducted in the Pediatric Outpatient Clinic and Ward at
Sanglah Hospital, Denpasar, Bali from January 2001-December
2003. All subjects were recorded for clinical and laboratory signs,
including initial symptoms, history of previous streptococcal infections,
blood pressure, complete blood count, serum albumin, ASTO
titer, complement C3 level, BUN, and serum creatinin. Erythrocyturia
and proteinuria follow-ups were done by recording urinalysis
findings for a six-month period after initial onset.
Results Thirty subjects 21 boys and 9 girls, mean age 8.7 (SD 2.5)
years] with PSAGN were enrolled in the study, 16 had hematuria with
edema. Twenty-one subjects had the history of upper respiratory tract
infections and 9 with skin infections. Mean systolic blood pressure was
141.3 (SD 21.8) mmHg, mean diastolic blood pressure was 90.8 (SD
16.3) mmHg, mean ASTO titer was 1103.3 (SD 686.1) IU/ml, and mean
complement C3 level was 42.2 (SD 15.5) mg/dl. Urinalysis monitoring
showed 2/30, 9/30, 12/30, 22/30, 27/30 subjects had conversion hematuria
at the first, second, third, fourth, and fifth month, respectively.
Median duration of erythrocyturia conversion was 4.0 months (95% CI:
3.53-4.47). There were 11/30, 18/30, 21/30, 23/30, 25/30, 26/30 subjects
with proteinuria conversion at the first, second, third, fourth, fifth,
and sixth month, respectively. Median duration of proteinuria conversion
was 2.0 months (95% CI: 1.25-2.75).

Item Type: Article
Subjects: L Education > L Education (General)
Divisions: Faculty of Law, Arts and Social Sciences > School of Education
Depositing User: USDI USDI Universitas Udayana
Date Deposited: 20 Jul 2020 12:24
Last Modified: 20 Jul 2020 12:24

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